Evaluation of the Role of Soluble Receptors for Advanced Glycosylated End-Products in Polycystic Ovarian Syndrome

    February 2016 in “ Evidence Based Women Health Journal (Online) ”
    Hossam Hassan Aly Hassan El Sokkary, Mona Sobhy, Wafaa Mostafa Abo Elenein, Heba Elesawy Mohamed
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    TLDR Women with PCOS had higher SRAGE levels, possibly linked to BMI, not PCOS.
    The study investigated serum levels of soluble receptors for advanced glycosylated end-products (SRAGE) in 30 women with polycystic ovarian syndrome (PCOS) and compared them to 30 women without PCOS, all aged 18-35 years. The results indicated an increase in serum SRAGE levels in the PCOS group compared to the control group; however, this increase was not statistically significant. Furthermore, there was a negative correlation between serum SRAGE levels and BMI and waist circumference in the PCOS group, but no correlation with hormonal parameters such as FSH, LH, and testosterone. The study suggested that while SRAGE levels were elevated in women with PCOS, this might be related to BMI rather than PCOS itself.
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