Risk Factors for Intraoperative Floppy Iris Syndrome: A Retrospective Study

This retrospective study involving 738 Caucasian patients undergoing phacoemulsification cataract surgery identified risk factors for intraoperative floppy iris syndrome (IFIS). IFIS was observed in 5.8% of cases, with current use of α1-blockers (tamsulosin, alfuzosin, terazosin), benzodiazepines, and finasteride independently associated with increased risk. Male sex and heart failure were not significant in multivariate analysis. The study highlighted a novel association between benzodiazepines and IFIS, suggesting that anxious patients should avoid benzodiazepines before surgery. Additionally, finasteride, rivastigmine, and quetiapine were noted as potential risk factors, warranting further investigation into their effects.