Further Observations on Riboflavin as a Food Factor in Economy of Food Utilization

    September 1941 in “ Journal of Nutrition ”
    Barnett Sure
    TLDR Riboflavin is essential for health and growth, and its deficiency causes serious health issues.
    This study on ten pairs of male rats using a paired feeding method revealed that riboflavin deficiency significantly impacts body weight gain and health. Riboflavin-deficient rats gained only 6.1 g on average over 125 days, compared to 61.3 g in controls receiving 20 μg of riboflavin daily. Unlike thiamine deficiency, riboflavin deficiency does not lead to severe anorexia but may result in varied food intake levels. Deficient rats exhibited symptoms such as alopecia, dermatitis, rough hair, conjunctivitis, keratitis, and premature senility. The study suggests that riboflavin is crucial for oxidative-enzymic processes, and its deficiency may lead to metabolic waste and organism collapse.
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