Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)

In 2003, the Rotterdam consensus workshop group revised the diagnostic criteria for polycystic ovary syndrome (PCOS), requiring two out of three features for diagnosis: oligo- and/or anovulation, clinical and/or biochemical signs of hyperandrogenism, and polycystic ovaries, while excluding other etiologies. The consensus recognized PCOS as a syndrome with a spectrum of clinical manifestations, including menstrual irregularities, androgen excess, obesity, insulin resistance, and elevated serum LH levels, and associated with increased risks of type 2 diabetes and cardiovascular events. It emphasized that PCOS is a diagnosis of exclusion and provided guidelines for related disorder exclusion, hyperandrogenism assessment, and polycystic ovaries definition via ultrasound. The document also discussed insulin resistance management, the use of an oral glucose tolerance test for metabolic syndrome screening in obese women with PCOS, and the uncertain role of LH in PCOS diagnosis. It highlighted the need for lifestyle interventions to reduce long-term health risks and called for further research to assess risk levels and intervention efficacy. The document did not specify the number of people involved in the consensus or in any referenced studies.