Reduction of Radiation-Induced Hair Loss by Topical Application of Radioprotectors

The study investigated the potential of reducing radiation-induced hair loss through the topical application of radioprotectors in mice. Researchers tested WR-1065, cysteine, and TEMPOL in various vehicles, including saline, DMF, PG, DMSO, and ethanol. The effectiveness of these protectors varied depending on the radiation dose and the vehicle used. At a dose of 600 R, both WR-1065 and cysteine reduced hair loss in any vehicle, while at 800 R, only WR-1065 in DMF and cysteine in saline provided some protection. TEMPOL in ethanol was effective at both 600 and 800 R. The findings suggested that the appropriate combination of protectors and vehicles could mitigate radiation-induced hair loss.