Possible Reasons for Urethral PSA Variations After Radical Prostatectomy

    January 2010 in “ Acta Chirurgica Iugoslavica ”
    T. Pejcic, Jovan Hadzi-Djokic, Biljana Marković, N. Lalic, B. Glisic
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    TLDR Higher urethral PSA levels after prostate removal may be linked to more scalp hair loss and more PSA in urethral glands.
    The study, conducted 13 years ago, examined the reasons for variations in urethral prostate specific antigen (urPSA) levels in 46 patients who had undergone radical prostatectomy. The average urPSA was found to be 20.9+47.5 ng/ml. Patients were divided into two groups based on a urPSA cut-off of 2.0 ng/ml: Group A (urPSA < 2.0 ng/ml) and Group B (urPSA = 2.0 ng/ml). The study found that patients in Group A had significantly lower average androgenic alopecia (AGA) scores and lower postoperative PSA levels than those in Group B. The conclusion was that patients with higher urPSA levels also had higher AGA scores and higher postoperative PSA levels, likely due to increased local dihydrotestosterone activity in the scalp and PSA-secreting urethral glands.
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