Real-Life Data for Tenofovir Alafenamide Fumarate Treatment of Hepatitis B: The Pythagoras Cohort

March 2021 in “ Hepatitis Monthly ”

Ömer Karaşahin, İrem Akdemir Kalkan, Tuba Dal, Sibel Altunışık Toplu, Murat Harputoğlu, Ayşe Özlem Mete, Süheyla Kömür, Figen Sarıgül Yıldırım, Yeşim Yıldız, Fatih Esmer, Özlem Kandemir, Selçuk Nazik, Dilara İnan, Fethiye Akgül, Şafak Kaya, Nurettin Tunç, Şafak Özer Balın, Yaşar Bayındır, Yeşim Taşova, Fesih Akar, Meryem Merve Ören, Merve Ayhan, Yakup Demir, Mustafa Kemal Çelen

tenofovir alafenamide fumarate tenofovir disoproxil fumarate hair loss nephrotoxicity bone density glomerular filtration rate T-scores phosphorus levels TAF TDF

TLDR Tenofovir alafenamide fumarate is effective and safer for hepatitis B, with fewer side effects than tenofovir disoproxil fumarate.

The study evaluated the effectiveness and safety of tenofovir alafenamide fumarate (TAF) in treating chronic hepatitis B using real-life data from 480 patients in southern Turkey. TAF was shown to be an effective and safe alternative to tenofovir disoproxil fumarate (TDF), with lower incidences of nephrotoxicity and decreased bone density. Patients switching from TDF to TAF experienced significant improvements in glomerular filtration rate, hip and spine T-scores, and phosphorus levels over 6 months. Side effects were reported by a small percentage of patients, with hair loss being the most common at 1%. Overall, TAF provided similar efficacy to TDF with fewer long-term side effects.

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