Fluid Loss Through Epidermis of the Rat and Factors Affecting It

    December 1954 in “ Experimental Biology and Medicine ”
    Earl O. Butcher
    TLDR Fluid loss through rat skin is minimal when inactive but increases with skin activity and hair growth.
    The study investigates fluid loss through the skin of rats, finding that it is minimal during the resting stage when the epidermis is thin and inactive, and the corneum is dry and brittle. Fluid loss increases as the skin becomes more active, particularly as hair growth approaches. Additionally, linoleic acid penetrates more during the inactive condition, which further accentuates water loss.
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