TLDR Raman spectroscopy can help identify cancerous skin tissue during surgery.
The study explored the use of Raman spectroscopy (RS) to identify biophysical differences between basal cell carcinoma (BCC) and normal skin structures in surgical margins. Using skin samples from 14 patients undergoing Mohs surgery, RS was employed to acquire images and analyze spectral data through K-means clustering and a biophysical model. The findings indicated significant differences in the fit coefficients of nucleus, collagen, triolein, keratin, and elastin between BCC and normal skin, suggesting RS's potential for detecting biophysical changes in resection margins. This supported the development of diagnostic algorithms for RS's future intraoperative use in Mohs surgery.
25 citations
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November 2010 in “Journal of Molecular Structure” Raman micro-spectroscopy can help distinguish basal cell carcinoma from hair follicles in skin tissue.
1 citations
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April 2017 in “Journal of Investigative Dermatology” A new one-step test can quickly identify skin cancer during surgery.
46 citations
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December 2018 in “Biomedical Optics Express” Raman spectroscopy could effectively guide skin cancer surgery by identifying tumor margins.
25 citations
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November 2010 in “Journal of Molecular Structure” Raman micro-spectroscopy can help distinguish basal cell carcinoma from hair follicles in skin tissue.
4 citations
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March 2013 in “InTech eBooks” Confocal Laser Scanning Microscopy (CLSM) is a useful tool for studying how drugs interact with skin and diagnosing skin disorders, despite some limitations.
1 citations
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July 2014 in “The journal of investigative dermatology/Journal of investigative dermatology” Light affects skin health, aging, and cancer risk, and new light-based treatments and imaging are promising for skin care.
