Drug Repurposing: Hypothesis, Molecular Aspects, and Therapeutic Applications

    April 2020 in “ IntechOpen eBooks ”
    Farid A. Badria, Mithun Rudrapal, Shubham J. Khairnar, Anil Jadhav, Anil Sandip, Deepak Kumar Dash, Vishal Jain, Kuleshwar Prasad Sahu, Rajnikant Panik, Murali Krishna Enduri, Deepak Kumar Dash, Anil Kumar Sahu, Abdullah A. Elgazar, Neha Dhir, Ashish Jain, Dhruv Mahendru, Harvinder Singh, Harvinder Singh, Xiao‐Yuan Mao, Andrea Vila Domínguez, Manuel Enrique, Jiménez Mejías, Younes Smani, Alkesh Patel, Sho Tamai, Nozomi Hirai, Shabierjiang Jiapaer, Takuya Furuta, Mitsutoshi Nakada
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    Studysummary The authors describe drug repurposing as a promising strategy for finding new uses for existing drugs, noting it is efficient, cost-effective, and poses lower risks than traditional drug discovery processes, potentially aiding in the treatment of rare and difficult-to-treat diseases.
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    The document discussed drug repurposing as an efficient and cost-effective strategy for finding new uses for existing drugs, with about 30% of FDA-approved drugs being repurposed. It highlighted successful examples like minoxidil for alopecia and sildenafil for erectile dysfunction. Drug repurposing was seen as promising for addressing rare and difficult-to-treat diseases by using existing safety data to speed up development. The economic impacts and potential of repurposing were explored in fields such as dermatology, oncology, and infectious diseases, emphasizing the balance between scientific research and clinical practice.
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