Peripherally-Derived Regulatory T Cells in Mouse Autoimmune Diabetes
January 2019
in “
eScholarship (California Digital Library)
”
TLDR Thymus-derived Tregs, not peripherally-derived Tregs, primarily regulate type 1 diabetes in the NOD mouse model.
The study investigated the role of peripherally-derived regulatory T cells (pTregs) in type 1 diabetes (T1D) using a non-obese diabetic (NOD) mouse model with a deletion of the CNS1 enhancer, crucial for pTreg generation. The findings indicated that CNS1-dependent pTregs did not significantly influence T1D development in these mice. Instead, thymus-derived Tregs (tTregs) were identified as the primary regulators of T1D. The study also found that Tregs in pancreatic islets mainly recognized antigens presented in the thymus, rather than peripherally-derived neoantigens. Despite increased insulitis, the absence of CNS1 did not lead to higher T1D incidence, suggesting that pTregs were not essential in this context.
