The study investigated the potential of using Prostate Specific Antigen (PSA) as a diagnostic marker for hyperandrogenic conditions in women by examining 105 girls aged 17-26. It was found that PSA concentration in peripheral blood increases with higher levels of testosterone (T) and dehydroepiandrosterone sulfate (DHEA-S), and decreases with lower levels of sex hormone-binding globulin (SHBG). The results suggest that PSA is a valuable marker for diagnosing hyperandrogenism in women, demonstrating a clear relationship between androgen levels and PSA concentration.
58 citations,
November 2020 in “International Journal of Molecular Sciences” SHBG may be a useful early indicator and treatment target for PCOS.
82 citations,
May 2016 in “Best Practice & Research in Clinical Obstetrics & Gynaecology” The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.
16 citations,
January 2000 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Antiandrogen drugs can reduce PSA levels in women with excess hair, suggesting PSA is a sign of male hormone activity in women.
19 citations,
July 2013 in “The obstetrician & gynaecologist” The document concludes that careful evaluation is needed to diagnose PCOS correctly due to similar symptoms in other conditions, and accurate testosterone level measurement is crucial.
56 citations,
October 1983 in “Archives of Dermatology” Some women with acne have higher levels of free testosterone, which might suggest using hormonal treatments for acne.
