Platelet-Rich Plasma Injections and Scalp Cutaneous Malignancies: Clinical Implications and Knowledge Gaps

April 2026 in “ International Journal of Dermatology ”

Archie Spindler, Derek Maas, Isabella Zappi, Olivia Perez, L. Petukhova, Nicole Doudican, John Carucci, Jennifer Stein, Jerry Shapiro, Maressa C. Criscito, Kristen I. Lo Sicco

platelet-rich plasma androgenetic alopecia cutaneous malignancy growth factors PDGF-mediated signaling photoprotection antiproliferative scalp surveillance PRP

Studysummary This review explores the potential links between PRP treatments for hair loss and scalp skin cancer risk, finding current evidence supports PRP's safety but emphasizes the need for further studies and routine monitoring.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

Platelet-rich plasma (PRP) injections are effective for treating androgenetic alopecia, but there are theoretical concerns about the risk of cutaneous malignancy due to concentrated growth factors in UV-exposed scalps. The article reviews hypotheses linking PRP to scalp skin cancer risk, including potential oncogenic mechanisms like PDGF-mediated signaling, and protective effects such as improved photoprotection and antiproliferative findings from related blood products. Although direct PRP-specific data are lacking, the evidence supports PRP's safety, highlighting the need for prospective studies, routine scalp surveillance, and patient counseling on photoprotection.

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research Effect of Liquid Blood Concentrates on Cell Proliferation and Cell Cycle and Apoptosis Related Gene Expressions in Nonmelanoma Skin Cancer Cells: A Comparative In Vitro Study

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research Autologous Platelet-Rich Plasma Treatment for Androgenic Alopecia: A Systematic Review and Meta-Analysis of Clinical Trials on Patient Safety, Efficacy and Outcomes

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This study found that autologous platelet-rich plasma significantly improved hair follicle number, thickness, and density in patients with androgenic alopecia compared to placebo, with high reported patient satisfaction.