Protective effects of wheat sprouts extract against acrylamide-induced skin toxicity: Modulation of oxidative stress, apoptosis, and histomorphometric alterations in rats

The study investigated the protective effects of wheat sprout (WSP) extract against acrylamide (ACR)-induced skin toxicity in 20 adult male rats over 21 days. ACR exposure resulted in reduced dermal thickness, collagen density, and hair follicle and sebaceous gland profiles, along with increased oxidative stress and apoptosis. Co-administration of WSP significantly countered these effects by preserving skin structure, enhancing antioxidant defenses, and modulating apoptotic markers. The study highlights WSP's role in enhancing total antioxidant capacity and superoxide dismutase activity while reducing reactive oxygen species and malondialdehyde levels, suggesting that WSP extract could serve as a sustainable protective agent against environmental skin toxins.