Prostanoid receptors in anagen human hair follicles
November 2007
in “Experimental dermatology”
TLDR Human hair follicles contain a complex network of prostanoid receptors that may influence hair growth.
The study from 2007 investigated the distribution of prostanoid receptors in anagen phase human hair follicles, which became of interest due to the hair growth effects observed with prostaglandin F2α receptor (FP) agonist treatments for intraocular pressure. The research utilized RT-PCR, Western blot, and immunohistochemistry (IHC) to demonstrate that all prostanoid receptors were present in the hair follicle. The findings revealed a complex network of receptor expression, with prostaglandin E2 receptors (EP2, EP3, EP4), prostaglandin D2 receptor (DP2), and thromboxane A2 receptor (TP) being widely expressed in various hair follicle compartments. In contrast, Prostaglandin I2 receptor (IP) and DP1 had more specific expressions in the hair cuticle layer and outer root sheath basal layer, respectively. FP expression was mainly found in the outer root sheath companion layer and dermal papilla. The study highlighted the complexity of the prostanoid receptor network in hair follicles and suggested that FP receptor activity could be linked to the effects of PGF2α on hair regrowth by influencing dermal papilla function.
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