Prostaglandin E ₂ Receptor 2 Modulates Macrophage Activity for Cardiac Repair

The study investigated the role of prostaglandin E2 receptor 2 (EP 2) in cardiac repair following myocardial injury using EP 2-deficient transgenic mice. It was found that the absence of EP 2 worsened cardiac function and impaired macrophage recruitment to the injured heart tissue. This deficiency also altered the proinflammatory response and increased the expression of erythroid differentiation regulator 1 (Erdr1) in macrophages. Knocking down Erdr1 restored the migration ability of EP 2-deficient cells. The research concluded that the EP 2-dependent signaling pathway was crucial for regulating macrophage recruitment and modulating the inflammatory environment necessary for cardiac repair.