Principles of Chemotherapy

Chemotherapy played a crucial role in treating gynecological malignancies but required careful patient and drug selection due to its narrow therapeutic window and severe adverse effects. Treatment goals varied from cure to palliation, necessitating histological verification of malignancy. Managing adverse effects like bone marrow suppression, gastrointestinal issues, and hair loss was essential, with specific strategies for hypersensitivity reactions, neutropenia, anemia, thrombocytopenia, and nausea/vomiting. Hair loss typically began within 2-3 weeks and was temporary, while peripheral neuropathy affected 30%-40% of patients without effective prevention. The document stressed the importance of specialized knowledge, strict protocols, and early rehabilitation to manage adverse effects and occupational hazards.