Preventive and Therapeutic Efficacy of Finasteride and Dutasteride in TRAMP Mice

The study investigated the effectiveness of finasteride and dutasteride in preventing and treating prostate cancer in TRAMP mice. The results showed that dutasteride was more effective than finasteride in inhibiting prostatic intraepithelial neoplasia progression and prostate cancer development. The study supports the therapeutic use of dutasteride, but not finasteride, for therapeutic or preventive use. Both drugs reduced prostate cancer incidence and delayed tumor progression, with dutasteride being more effective than finasteride. The drugs also reduced serum prostate-specific antigen levels and prostate weight. The study suggests that both drugs have potential for preventing and treating prostate cancer in humans.