Preliminary report of intraovarian injections of autologous platelet-rich plasma (PRP) in extremely poor prognosis patients with only oocyte donation as alternative: a prospective cohort study

This study investigated the effects of intraovarian injections of autologous platelet-rich plasma (PRP) on ovarian function in 80 women with extremely low functional ovarian reserve (LFOR), who otherwise would likely require oocyte donation for pregnancy. Over a 1-year follow-up, no clinically significant improvements in ovarian function were observed. Although two 40-year-old patients achieved pregnancy, resulting in a 4.7% ongoing pregnancy rate among those who produced at least one oocyte, these outcomes may be due to regression to the mean rather than the PRP treatment itself. The study concluded that while sporadic pregnancies are possible in poor prognosis patients, the results do not support PRP as an effective treatment for improving ovarian function. Further research with more controlled patient selection is needed.