Evaluation of Porcine-Derived Placental Powder for Skin Wound Healing in a Rat Model

This study evaluated the effectiveness of porcine-derived placental biomaterials in treating skin wounds using a rat model. The study involved 36 rats and compared porcine-derived placental powder (PP) and membrane (PM) to human-derived amniotic membrane (HM) and no treatment. Results showed no significant statistical differences between the treatment groups in terms of wound area, histological inflammation, and collagen quantification. However, PP-treated defects exhibited lower gross inflammation scores compared to HM at Day 3 and demonstrated trends of greater healing efficacy at earlier timepoints. PP-treated wounds showed improved outcomes such as reduced inflammation, enhanced hair follicle growth, re-epithelialization, and collagen formation, suggesting that porcine-derived placental biomaterials may be a viable alternative to human-derived products for wound healing.