TLDR Porcine and human pilosebaceous units are very similar.
The study examined the histochemistry of the porcine pilosebaceous unit, focusing on lectin and immunoreactivity. It found that complex carbohydrates, such as mucin and biantennary Man/Gluc types, were present in various parts of the hair follicle epithelia, while sebaceous glands expressed biantennary Man/Gluc carbohydrates and GalNAc residues. Immunohistochemistry confirmed the presence of simple-type and epidermis-like keratins, with filaggrin-positive cells located in the keratinizing zone of HENLE'S layer in anagen follicles. The innermost layer of the outer hair root sheath showed staining for epidermal growth factor-receptor, keratin 10, and Ki67 antigen. The study noted minimal differences between porcine and human pilosebaceous units.
124 citations
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December 1988 in “Differentiation” Trichocytic differentiation starts in cells with epithelial cytokeratins, transitioning to trichocytic cytokeratins in hair and gradually in nails.
248 citations
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April 1988 in “Differentiation” Human and bovine hair follicles have distinct cytokeratins specific to hair-forming cells.
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” A specific mutation in the TRPV3 gene causes hair follicle cells to develop improperly, leading to hair loss.
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February 2004 in “British Journal of Dermatology” Keratin in mouse hair follicles is complex and plays specific roles.
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135 citations
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59 citations
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August 1981 in “PubMed” Trichilemmal keratinization is a unique process in hair follicles where the outer root sheath turns into keratin without a specific layer.
