30 citations
,
February 2016 in “British journal of dermatology/British journal of dermatology, Supplement” This review found moderate to very low-quality evidence that spironolactone, flutamide, and cyproterone acetate combined with oral contraceptives may reduce hirsutism more effectively than placebo or metformin, though results vary among other treatments.
14 citations
,
January 2008 in “Dermatology Online Journal” This review discusses the use of anti-hormonal therapies for female androgenetic alopecia and notes that while some treatments show promise, larger controlled studies are needed to define their roles and effectiveness.
75 citations
,
November 2007 in “Clinical endocrinology” This study found that several drugs, including flutamide and spironolactone, significantly reduced hirsutism in women, with reduced effectiveness in those with higher BMI.
195 citations
,
May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology” This review discusses the diagnosis and treatment of hirsutism, emphasizing that a systematic evaluation can determine its cause, while combination therapy effectively manages the condition for most patients.
55 citations
,
March 2000 in “American journal of clinical dermatology” Antiandrogens, particularly flutamide and CPA, are most effective for treating hirsutism, with long-term use needed for best results.
20 citations
,
January 1999 in “Current Pharmaceutical Design” This study reports that various antiandrogen therapies, including spironolactone and finasteride, effectively address hirsutism, acne, androgenic alopecia, and ovulatory dysfunction in hyperandrogenic women and are generally well tolerated.
