Paroxysmal Nocturnal Hemoglobinuria in Systemic Lupus Erythematosus: A Rare Manifestation

January 2023 in “ PubMed ”

Md Nazmul Hasan, S B Rahman, Mostafizur Rahaman, S K Biswas, I Ahmed, Md Ashiqur Rahman

systemic lupus erythematosus hair loss photosensitivity oral ulcers anemia paroxysmal nocturnal hemoglobinuria PNH flow cytometry SLE

TLDR PNH can occur in patients with SLE, so doctors should be aware of this.

A 19-year-old woman with systemic lupus erythematosus (SLE) presented with symptoms including fever, joint pain, photosensitivity, oral ulcers, and hair loss. She was admitted to Bangabandhu Sheikh Mujib Medical University in Dhaka, Bangladesh, and subsequently developed progressive anemia and dark-colored urine. Flow cytometry analysis revealed a paroxysmal nocturnal hemoglobinuria (PNH) clone within her red cells. This case highlights the rare occurrence of PNH in SLE patients, emphasizing the need for clinicians to be aware of this potential association.

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