Study of the Expression of Pluripotency Markers in Idiopathic Inflammatory Bowel Diseases
November 2018
TLDR OCT4B1 and SOX-2 levels are higher in Crohn's and ulcerative colitis patients, possibly aiding tissue repair.
The study investigated the expression patterns of OCT4 variants and SOX-2 in tissue and blood samples from patients with inflammatory bowel disease (IBD), specifically Crohn's disease (CD) and ulcerative colitis (UC). It was found that OCT4 protein levels were significantly higher in CD tissue samples compared to CD blood samples and UC tissue samples. The research highlighted the differential expression of OCT4 splicing variants in pluripotent and non-pluripotent cells, emphasizing the role of OCT4 and SOX-2 in maintaining stem cell pluripotency and self-renewal. The study utilized methods such as Western blot, immunohistochemistry, and reverse transcription-real-time PCR to document these findings.
