Platelet-rich autoplazma effect on intestinal anastomosis regeneration in rabbits

The study evaluated the effect of platelet-rich plasma (PRP) on intestinal anastomosis regeneration in 81 rabbits, comparing two application methods: injection into the muscle layer and soaking in the intestinal wall. Results indicated that both PRP treatments improved regeneration compared to the control group, as evidenced by better histological and morphometric outcomes, including reduced inflammatory infiltrate, increased fibroblast proliferation, neoangiogenesis, and collagen deposition. However, PRP soaking led to significant adhesion formation and lumen narrowing, while PRP injection reduced adhesion development. The rupture strength of anastomoses was higher in PRP-treated groups. The study concluded that PRP application positively affected intestinal anastomosis regeneration, with injections into the muscle layer being more favorable due to fewer adhesions, and suggested further research to determine the optimal PRP application method.