Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme During the Hair Growth Cycle: Implications for Growth Control and Hair Follicle Transformations
![Image of study](/images/research/550155b6-bcc9-4f17-a1d8-f5d9c135394b/medium/29586.jpg)
TLDR Disruptions in hair follicle fibroblast dynamics can cause hair growth problems.
The document discussed the complex interactions between the hair follicle's epithelial and mesenchymal components, particularly focusing on the changes in hair follicle fibroblast subpopulations during the hair growth cycle. It highlighted that while much attention had been given to the hair follicle epithelium, the dynamics of fibroblasts were less understood. The review synthesized current literature and summarized a recent study by the authors, suggesting that disruptions in fibroblast dynamics could lead to various clinical issues related to human hair growth.
View this study on jidsponline.org →
Discuss this study in the Community →
Cited in this study
11 / results![Possible mechanisms of miniaturization during androgenetic alopecia or pattern hair loss](/images/research/e09bdb73-9034-4673-b4c2-bf237fa3121d/small/2364.jpg)
research Possible mechanisms of miniaturization during androgenetic alopecia or pattern hair loss
Hair loss occurs due to fewer papillary cells, smaller follicles, and shorter growth phases.
![Towards a molecular understanding of hair loss and its treatment](/images/research/f74753b4-62c7-4beb-b1e8-6c020af2eb70/small/25161.jpg)
research Towards a molecular understanding of hair loss and its treatment
Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.
![Role of hair papilla cells on induction and regeneration processes of hair follicles](/images/research/07c6abd9-1b86-4495-b64c-f7d50551b125/small/20050.jpg)
research Role of hair papilla cells on induction and regeneration processes of hair follicles
Hair papilla cells can create and regenerate hair bulbs under the right conditions.
![Human Hair Follicle Regeneration Following Amputation and Grafting into the Nude Mouse](/images/research/cd86d64b-76f8-4c21-a0bb-2a341426c65e/small/2134.jpg)
research Human Hair Follicle Regeneration Following Amputation and Grafting into the Nude Mouse
Human hair follicles can regenerate after removal, but with low success rate.
research DERMAL-EPIDERMAL INTERACTIONS
Hair loss is mainly caused by hormones, autoimmune issues, and chemotherapy, and needs more research for treatments.
research The upper dermal sheath has a potential to regenerate the hair in the rat follicular epidermis
The upper dermal sheath can regenerate hair in rats.
![Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth.](/images/research/13748671-10eb-46eb-8a68-c62729f76974/small/35033.jpg)
research Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth.
Hair color production is closely linked to the active growth phase of hair in mice and may also influence hair growth itself.
research The secret life of the hair follicle
Hair follicles create different cell layers and proteins, controlled by various molecules.
research Dermal-epidermal interactions
The dermal papilla interacts with the epidermis to control hair growth and development.
![Normal Hair Growth in Children](/images/research/242a3228-8586-4679-a8f3-7b4fe6f152ee/small/21182.jpg)
research Normal Hair Growth in Children
Children's hair grows in different types from before birth through puberty, with growth rates and characteristics varying by age, sex, and race.
![Action of topical minoxidil in the bald stump-tailed macaque](/images/research/55892997-06e3-4329-b964-2c2b2fad4ea8/small/1870.jpg)
research Action of topical minoxidil in the bald stump-tailed macaque
Minoxidil promotes hair growth but stops working when discontinued.
Related
1 / results![Blockade of S100A3 Activity Inhibits Murine Hair Growth](/images/research/39d0c6de-d4cd-4d74-95e6-c2cd6582a427/small/19700.jpg)
research Blockade of S100A3 Activity Inhibits Murine Hair Growth
Stopping S100A3 activity slows down hair growth in mice.