Synthesis and Characterization of Polyethylene Glycol-Coated Magnetic Nanoparticles and Their Use in Anti-Cancer Drug Delivery
January 2014
in “
Spectrum Research Repository (Concordia University)
”
TLDR FA-MNPs effectively targeted and killed cancer cells but didn't overcome drug resistance.
The study focused on synthesizing and characterizing folic acid conjugated, polyethylene glycol-coated magnetic nanoparticles (FA-MNPs) and doxorubicin-loaded formulations (Dox-FA-MNPs) for targeted cancer treatment. The nanoparticles were successfully synthesized and characterized, demonstrating supermagnetic behavior and effective drug loading and release, particularly in acidic conditions. Internalization experiments confirmed uptake by HeLa cells, and cytotoxicity assays showed that Dox-FA-MNPs significantly reduced proliferation in HeLa cells but not in doxorubicin-resistant HeLa/Dox cells. Despite not overcoming drug resistance, Dox-FA-MNPs effectively targeted and killed HeLa cells, highlighting the potential of FA-MNPs in drug delivery systems.