Ovarian Morphology Is Associated With Insulin Resistance In Women With Polycystic Ovary Syndrome: A Cross-Sectional Study

    May 2017 in “ Fertility Research and Practice ”
    Sara Pittenger Reid, Chia-Ning Kao, Lauri A. Pasch, Kanade Shinkai, Marcelle I. Cedars, Heather G. Huddleston
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    TLDR Larger ovarian size is linked to higher insulin resistance in women with PCOS.
    In the 2017 study involving 313 women with polycystic ovary syndrome (PCOS), researchers found a significant association between increased ovarian volume and markers of insulin resistance. Women with an ovarian volume greater than 10 cc had a 1.9 times higher odds of elevated Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and a 1.8 times higher odds of abnormal fasting insulin levels compared to those with smaller ovarian volumes. The number of follicles, however, did not show a significant correlation with metabolic parameters. The findings suggest that ovarian volume could be a useful indicator for assessing metabolic risk in PCOS patients, while follicle count may not be predictive of such risks.
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