Ovarian Morphology Is Associated With Insulin Resistance In Women With Polycystic Ovary Syndrome: A Cross-Sectional Study

May 2017 in “ Fertility Research and Practice ”

Sara Pittenger Reid, Chia-Ning Kao, Lauri A. Pasch, Kanade Shinkai, Marcelle I. Cedars, Heather G. Huddleston

polycystic ovary syndrome PCOS insulin resistance ovarian volume Homeostatic Model Assessment for Insulin Resistance HOMA-IR fasting insulin levels metabolic risk fasting insulin

Studysummary This study found that increased ovarian volume is associated with markers of insulin resistance in women with polycystic ovary syndrome, while follicle number was not linked to metabolic risk. Our plain-language summary of this paper — not a Tressless recommendation.

In the 2017 study involving 313 women with polycystic ovary syndrome (PCOS), researchers found a significant association between increased ovarian volume and markers of insulin resistance. Women with an ovarian volume greater than 10 cc had a 1.9 times higher odds of elevated Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and a 1.8 times higher odds of abnormal fasting insulin levels compared to those with smaller ovarian volumes. The number of follicles, however, did not show a significant correlation with metabolic parameters. The findings suggest that ovarian volume could be a useful indicator for assessing metabolic risk in PCOS patients, while follicle count may not be predictive of such risks.

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Research cited in this study

8 / 8 results

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research Prevalence of Androgenic Alopecia in Patients with Polycystic Ovary Syndrome and Characterization of Associated Clinical and Biochemical Features

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The Prevalence of Polycystic Ovary Syndrome in a Normal Population According to the Rotterdam Criteria Versus Revised Criteria Including Anti-Mullerian Hormone

research The Prevalence of Polycystic Ovary Syndrome in a Normal Population According to the Rotterdam Criteria Versus Revised Criteria Including Anti-Mullerian Hormone

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This study found that the prevalence of polycystic ovary syndrome was 16.6% with Rotterdam criteria but decreased to 6.3% or 8.5% when using alternative criteria involving antral follicle count or anti-Müllerian hormone.

research Clinical and Endocrine Characteristics of the Main Polycystic Ovary Syndrome Phenotypes

145 citations , March 2010 in “Fertility and Sterility”

This study reported that ovulatory PCOS is a milder form of the condition compared to classic PCOS phenotypes, which share similar clinical and hormone characteristics.

research Metabolic Features of the Reproductive Phenotypes of Polycystic Ovary Syndrome

286 citations , January 2009 in “Human Reproduction Update”

This study reports that NIH PCOS is linked to more severe metabolic issues, including higher obesity and insulin resistance, compared to non-NIH PCOS phenotypes.

research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report

1540 citations , October 2008 in “Fertility and Sterility”

This review discusses the definition of polycystic ovary syndrome proposed by the AE-PCOS Society Task Force, emphasizing hyperandrogenism, ovarian dysfunction, and excluding related disorders, while noting potential variations needing more research.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

4809 citations , January 2004 in “Fertility and Sterility”

This review discusses polycystic ovary syndrome, emphasizing its broad range of manifestations and associations with risks like type 2 diabetes and cardiovascular events, but reports no new clinical results.

research Prevalence of Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study

633 citations , September 1998 in “The Journal of Clinical Endocrinology and Metabolism”

This study observed that among a cohort of reproductive-aged women in the U.S., the prevalence of PCOS was about 4.0%, with no significant racial differences between White and Black women.

research Polycystic Ovary Syndrome: Clinical and Biochemical Features

1947 citations , September 1995 in “New England journal of medicine/The New England journal of medicine”

This article discusses the heterogeneity of polycystic ovary syndrome, its association with insulin resistance, and its implications for long-term health, but reports no new clinical results.