Effectiveness and Safety of Oral Janus Kinase Inhibitors in Patients Aged 12 or Younger With Alopecia Areata: A Systematic Review and Meta-Analysis
March 2026
in “
Mendeley Data
”
TLDR Janus kinase inhibitors help hair regrowth in kids with alopecia areata but need more safety research.
The systematic review and meta-analysis evaluated the effectiveness and safety of oral Janus kinase inhibitors in children aged ≤12 with alopecia areata. The study included various analyses such as pooled outcomes for SALT change, complete scalp hair regrowth, and adverse events. Subgroup analyses were conducted based on medicine type, alopecia subtype, age group, and continent. The findings support the use of Janus kinase inhibitors in this demographic, highlighting significant hair regrowth and manageable adverse events, although the study emphasizes the need for further research to confirm long-term safety and efficacy.
