Effects of Oral Contraceptives on the Quality of Life of Women with Polycystic Ovary Syndrome: A Crossover Randomized Controlled Trial

June 2020 in “ Research Square (Research Square) ”

Mina Amiri, Fatemeh Nahidi, Razieh Bidhendi Yarandi, Davood Khalili, Maryam Tohidi, Fahimeh Ramezani Tehrani

oral contraceptives polycystic ovary syndrome levonorgestrel desogestrel cyproterone acetate drospirenone hirsutism obesity-menstrual disorders OCs PCOS LNG DSG CPA DRSP

TLDR Oral contraceptives with CPA improve overall quality of life for women with PCOS.

This study evaluated the effects of oral contraceptives (OCs) on the quality of life (QOL) in women with polycystic ovary syndrome (PCOS) through a crossover randomized controlled trial involving 200 participants, with 88 completing the study. The trial compared OCs containing levonorgestrel (LNG) with those containing desogestrel (DSG), cyproterone acetate (CPA), or drospirenone (DRSP) over two 6-month treatment periods. Results indicated that after 6 months, OCs containing CPA significantly improved the total QOL scores compared to those containing LNG (P < 0.042), while no significant differences were observed in specific QOL domains such as psychosocial-emotional, self-image, fertility, sexual function, hirsutism, and obesity-menstrual disorders. The study concluded that newer generation progestins in OCs were non-inferior to older compounds, with CPA showing notable improvements in overall QOL for PCOS patients.

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Related Research

3 / 3 results

Effects of Oral Contraceptives on the Quality of Life of Women with Polycystic Ovary Syndrome: A Crossover Randomized Controlled Trial

research Effects of Oral Contraceptives on the Quality of Life of Women with Polycystic Ovary Syndrome: A Crossover Randomized Controlled Trial

7 citations, August 2020 in “Health and Quality of Life Outcomes”

Birth control pills containing cyproterone acetate improve the quality of life more for women with polycystic ovary syndrome after 6 months of use.

research Effects of Oral Contraceptives on the Quality of Life of Women with Polycystic Ovary Syndrome: A Crossover Randomized Controlled Trial

June 2020 in “Research Square (Research Square)”

Oral contraceptives with CPA improve overall quality of life for women with PCOS.

research Effects of Oral Contraceptives on the Quality of Life of Women with Polycystic Ovary Syndrome: A Crossover Randomized Controlled Trial

April 2020 in “Research Square (Research Square)”

Oral contraceptives with cyproterone acetate improved quality of life for women with PCOS more than those with levonorgestrel.