Fertilizer Advisory System NAWSALD as an Aid in Sustainable Nutrient Management

January 2004 in “ Wieś Jutra ”

T. Jadczyszyn

testosterone finasteride androgenetic alopecia type I procollagen transforming growth factor-beta 1 human scalp dermal fibroblasts perifollicular fibrosis AGA TGF-beta1

TLDR Finasteride reduces hair loss by blocking testosterone's effects on scalp cells.

The study explored the role of testosterone (T) and finasteride in androgenetic alopecia (AGA), focusing on the expression of type I procollagen and transforming growth factor-beta 1 (TGF-beta1) in human scalp dermal fibroblasts. Testosterone treatment increased type I procollagen and TGF-beta1 expression, contributing to perifollicular fibrosis in AGA. Finasteride pretreatment inhibited these effects, reducing type I procollagen expression by 40.2% at the mRNA level and 24.9% at the protein level, and decreasing TGF-beta1 protein expression by 30.4%. The study suggested that finasteride's inhibitory effects on T-induced procollagen and TGF-beta1 expression might explain its mechanism in treating AGA.

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in Research/Science 679 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

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in Research/Science 363 upvotes 1 week ago

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community Why does it seem everyone favors finasteride over dutasteride?

in Female 62 upvotes 1 year ago

The conversation discusses preferences for hair loss treatments, specifically finasteride over dutasteride. Users share personal experiences, cost considerations, FDA approval status, and potential side effects, with some switching between treatments to find what works best for them.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 2 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community Why you should use 0.5mg Dut instead of 1mg Fin

in Finasteride/Dutasteride 45 upvotes 3 years ago

The comparison of 0.5mg dutasteride and 1mg finasteride for treating hair loss in men with androgenetic alopecia, with discussion of which is more effective and has fewer side effects.

community FCE 28260: A Forgotten 5α-Reductase Inhibitor

nkrata in Research 330 upvotes 1 year ago

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