Design of Nanocrystalline Suspension of Dutasteride for Intramuscular Prolonged Delivery

November 2024 in “ Nanomaterials ”

Min Young Jeong, Doe Myung Shin, Min Kyeong Kwon, Ye Bin Shin, Jun Soo Park, In Gyu Yang, Jin Hyuk Myung, Dong Geon Lee, G Lee, Chang‐Soo Park, Ji Won Yeo, Myoung Jin Ho, Yong Seok Choi, Myung Joo Kang

dutasteride nanocrystalline suspension intramuscular delivery benign prostatic hyperplasia scalp hair loss sustained drug release granulomatous inflammatory response Avodart

TLDR The nanocrystalline suspension effectively delivers dutasteride over time with minimal inflammation.

The study developed a nanocrystalline suspension (NS) of dutasteride (DTS) for prolonged intramuscular delivery, using a dual-centrifugation bead-milling technique with Tween 80 as a stabilizer. The DTS-NS achieved a particle size of 324 nm and demonstrated a sustained drug release profile in rats, maintaining therapeutic levels for over 56 days with a bioavailability of approximately 67%. Histopathological analysis showed a granulomatous inflammatory response at the injection site, which significantly decreased by day 14 and was minimal by day 28. These findings suggest that the DTS-NS system is promising for sustained drug delivery with manageable local inflammation, offering potential improvements in the delivery and efficacy of DTS in clinical settings.

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