Design of Nanocrystalline Suspension of Dutasteride for Intramuscular Prolonged Delivery

    November 2024 in “ Nanomaterials ”
    Min Young Jeong, Doe Myung Shin, Min Kyeong Kwon, Ye Bin Shin, Jun Soo Park, In Gyu Yang, Jin Hyuk Myung, Dong Geon Lee, G Lee, Chang‐Soo Park, Ji Won Yeo, Myoung Jin Ho, Yong Seok Choi, Myung Joo Kang
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    TLDR The nanocrystalline suspension effectively delivers dutasteride over time with minimal inflammation.
    The study developed a nanocrystalline suspension (NS) of dutasteride (DTS) for prolonged intramuscular delivery, using a dual-centrifugation bead-milling technique with Tween 80 as a stabilizer. The DTS-NS achieved a particle size of 324 nm and demonstrated a sustained drug release profile in rats, maintaining therapeutic levels for over 56 days with a bioavailability of approximately 67%. Histopathological analysis showed a granulomatous inflammatory response at the injection site, which significantly decreased by day 14 and was minimal by day 28. These findings suggest that the DTS-NS system is promising for sustained drug delivery with manageable local inflammation, offering potential improvements in the delivery and efficacy of DTS in clinical settings.
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