Improvement of Dermal and Transdermal Therapies by Nanocarrier-Based Drug Delivery

The document discussed the potential of nanocarrier-based drug delivery systems to improve dermal and transdermal therapies. Nanocarriers, which are nanoscale vehicles, were explored for their ability to transport drugs through the skin's complex barriers, including physical and immunological defenses. The study highlighted that hair follicles could serve as reservoirs for drug delivery, allowing nanoparticles to accumulate and interact with skin cells. Various nanocarrier characteristics, such as size, surface functionalization, and thermoresponsivity, were modulated to enhance drug targeting to specific skin areas or immune cells. The findings suggested that by adjusting these characteristics, it was possible to achieve selective targeting, potentially improving treatments for skin conditions by modulating immune responses. However, systematic studies were still needed to fully understand the correlation between nanocarrier properties and their effectiveness in skin penetration and drug delivery.