Improvement of Dermal and Transdermal Therapies by Nanocarrier-Based Drug Delivery

The document discussed the potential of nanocarrier-based drug delivery systems to improve dermal and transdermal therapies by overcoming the skin's physical and immunological barriers. Nanocarriers, which are nanoscaled vehicles, could be tailored in terms of size, surface functionalization, and other characteristics to target specific skin areas or immune cells, such as dendritic cells (DCs). The research highlighted the ability of nanocarriers to accumulate in hair follicles, deliver drugs like the HIV-1 p24 peptide, and enhance skin hydration and permeability. Despite the promising applications, systematic studies were needed to better understand the correlation between nanocarrier properties and their effectiveness in drug delivery and biocompatibility. The findings suggested that nanocarrier-based approaches could enhance the selectivity and efficacy of treatments for various skin conditions by targeting and modulating the activity of key immune cells.