Nail Loss After Teriflunomide Treatment: A New Potential Adverse Event

The document describes a case where a 55-year-old female patient with Multiple Sclerosis experienced nail loss after being treated with teriflunomide. This adverse event was not linked to other potential causes such as diet, new drugs, or cosmetics, and was not due to nail mycosis, psoriasis, or other nail dystrophies, as confirmed by a dermatologist. The nail loss was reversible; the patient's nails began to regrow and normalize after she stopped taking teriflunomide and underwent an accelerated removal procedure with oral colestiramine, followed by a new treatment with dimethyl-fumarate. This case indicates that nail loss may be a potential side effect of teriflunomide, and MS specialists should be aware of this possibility, which could necessitate discontinuation of the treatment.