Molecular Mechanisms of Donor Dominance in Androgenetic Alopecia

April 2018 in “ Journal of Investigative Dermatology ”

Y. Doucet, J. C. Chen, Hasan E. Abaci, Colin A.B. Jahoda, Angela M. Christiano

androgenetic alopecia AGA RNA seq differential gene expression cranial-caudal axis biosignatures genetic factors epigenetic factors developmental factors hair follicle scalp dermis parietal scalp occipital scalp hair loss gene expression skin development hair pattern scalp

TLDR Hair pattern in androgenetic alopecia overlaps with scalp and bone demarcations, with distinct gene profiles affecting susceptibility.

The study investigates the molecular mechanisms of donor dominance in androgenetic alopecia (AGA) and found that the hair pattern in AGA overlaps with the demarcations of scalp dermis/underlying bones. Computational analyses of RNA seq from parietal and occipital scalp of matching control and AGA affected volunteers revealed a differential gene expression profile along the cranial-caudal axis defining two distinct biosignatures that reflect the developmental origins of the skin and the susceptibility to develop AGA. The study provides novel insights into the genetic, epigenetic, and developmental factors required for temporal specification of the skin and the interdependence of hair follicle, skull and craniofacial development.

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research Androgenetic Alopecia: An Autosomal Dominant Disorder

80 citations, January 1995 in “The American Journal of Medicine”

Hair loss in androgenetic alopecia is caused by genetic factors and androgen excess, and can be treated with combined therapies.