Minoxidil Overdose: Severe Hypotension and Tachycardia After Ingestion

    April 1993 in “ Chest ”
    Andrew M. MacMillan, F.J. Warshawski, Richard Steinberg
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    TLDR Man drank minoxidil, caused low blood pressure and fast heartbeat, treatment helped but led to heart damage.
    A man ingested 60 ml of 2 percent topical minoxidil solution, resulting in severe hypotension and tachycardia. He was treated with intravenously administered crystalloid solution, dopamine, and phenylephrine infusion, resulting in a partial hemodynamic improvement and resolution of hypotension. The patient suffered a non-Q-wave myocardial infarction as a result of the ingestion. Minoxidil is originally used as an antihypertensive agent and is now approved for the treatment of male pattern baldness. The toxicity of this increasingly common preparation is profound.
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