Minoxidil (Mx) as a prophylaxis of doxorubicin – induced alopecia

    October 1994 in “ Annals of Oncology
    Rosana Rodriguez, M Machiavelli, Bernardo Amadeo Leone, Alessandra Romero, M A Cuevas, M. J. Langhi, L. Romero Acuna, J. M. Romero Acuna, Sandra Amato, Mauro Barbieri, Carlos Teodoro Vallejo, Mikhail I. Rabinovich, J. A. Coarasa Perez, C Sabatini, Ernesto Ortiz, Maurizio Salvadori, J. A. Lacava
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    TLDR Minoxidil not effective in preventing chemotherapy-induced hair loss.
    The study evaluated the effectiveness of Minoxidil (Mx) 2% topical solution in preventing doxorubicin-induced alopecia in 48 female cancer patients. The patients were randomly assigned to receive either Mx or a placebo, and both groups showed severe alopecia with no significant difference between them. The study concluded that Mx 2% topical solution was non-toxic but not effective in preventing chemotherapy-induced alopecia. The study suggests that few trials have been conducted to prevent chemotherapy-induced alopecia, and Mx, which is used to induce hair growth in men with male-pattern baldness, was not effective in preventing doxorubicin-induced alopecia.
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