Effect of Miliacin on Structural and Functional Characteristics of Skin Appendages of C57BL/6 Mice in an Experimental Model of Androgenetic Alopecia

The study conducted on 30 male C57BL/6 mice over 28 days investigated the effects of miliacin on androgenetic alopecia (AGA). The results showed that topical application of miliacin increased hair follicle density, increased the ratio of hair follicles in the growth stage to the resting stage, extended the duration of the growth stage, and reduced the variability of outer root sheath diameters. This suggests that miliacin can prevent the formation of morphological signs of AGA. Additionally, miliacin was found to potentially neutralize the effects of testosterone on the structure and functions of hair follicles, indicating similar effects to minoxidil on the structural reorganization of hair follicles in the AGA model.