Micronization Process of Hinokitiol Using Supercritical Carbon Dioxide

The document from 10 years ago detailed a study on the micronization of Hinokitiol, a compound widely used as a hair growth-promoting agent and anti-inflammatory compound in cosmetics and pharmaceuticals. The study aimed to improve the bioavailability of Hinokitiol by reducing its particle size using the rapid expansion of a supercritical solution, specifically supercritical carbon dioxide. The effects of temperature (313.15~333.15 K) and pressure (10.0~15.0MPa) on the particle size were investigated. Results showed that an isobaric increase in temperature led to an increase in the average particle size from 1.74 to 2.76 μm, while an isothermal increase in pressure resulted in a decrease in the average particle size from 2.21 to 1.14 μm. The effects of temperature and pressure on particle size were also assessed through solubility data and thermodynamic behavior.