Comparison of Therapeutic Efficacy of Microneedling With Platelet-Rich Plasma Plus 5% Minoxidil and 5% Minoxidil Alone in Androgenetic Alopecia

June 2025 in “ Journal of Population Therapeutics and Clinical Pharmacology ”

Harmeet Singh, Minakshi Narah, Krishna Talukdar, Balu Haridas, Porimollika Boruah, Anirban Roy, Pallabi Hatikakoty

minoxidil microneedling platelet-rich plasma androgenetic alopecia pruritus seborrheic dermatitis headache Rogaine PRP AGA

TLDR The combination of microneedling, PRP, and minoxidil is more effective for hair loss than minoxidil alone.

The study compared the efficacy of 5% minoxidil alone versus a combination of minoxidil, microneedling, and platelet-rich plasma (PRP) in treating androgenetic alopecia (AGA) in 50 patients aged 18-50. Group B, which received the combination treatment, showed significantly superior outcomes at 6 months compared to Group A, which received only minoxidil. The study found that the combination therapy is more effective, with mild adverse effects such as pruritus, seborrheic dermatitis, and headache. The authors suggest that PRP is a safe and effective adjunct, but recommend further research with standardized protocols and larger studies.

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