The Microbiome in Hair Disorders

    January 2019
    Andy Goren, Maja Kovačević, J. Philip McCoy, Mirna Šitum, Željana Bolanča, Andrija Stanimirović, Rachita Dhurat, Jill Chitalia, Aseem Sharma, Torello Lotti
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    TLDR Changes in skin bacteria can affect hair loss and new treatments targeting these bacteria may prevent balding without sexual side effects.
    The document from 2019 explores the connection between the skin microbiome and hair disorders, noting that microbial communities are influenced by physiological factors and remain generally stable over time. It details how alterations in the microbiome contribute to conditions like acne and hidradenitis suppurativa, and suggests that the microbiome could be utilized in treating hair disorders such as alopecia universalis and androgenetic alopecia. The document also proposes a novel treatment for pattern baldness by genetically engineering P. acnes to degrade testosterone, thereby reducing dihydrotestosterone (DHT) and potentially preventing hair loss without the sexual side effects associated with current treatments like finasteride.
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      in Research  830 upvotes 5 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.
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      in Chat  317 upvotes 1 year ago
      The conversation highlights the general public's lack of knowledge about hair loss, with various ineffective remedies suggested, such as not wearing hats or using hair fibers. The only effective treatments mentioned for male pattern baldness are medications like minoxidil and finasteride, and hair transplants.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  41 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community My progress lmk if you need advice 22 years old

      in Is this regrowth?  189 upvotes 4 weeks ago
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      community Scalp, eyebrow, eyelash and pubic hair loss.

       6 upvotes 6 years ago
      The user experienced significant hair loss on the scalp, eyebrows, eyelashes, and pubic area, along with itchy, flaky skin and red patches. They have a history of eczema and dermatitis and suspect that stopping shampoo use and taking Ritalin may have contributed to the issue.

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