The Microbiome in Hair Disorders

    January 2019
    Andy Goren, Maja Kovačević, J. Philip McCoy, Mirna Šitum, Željana Bolanča, Andrija Stanimirović, Rachita Dhurat, Jill Chitalia, Aseem Sharma, Torello Lotti
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    TLDR Changes in skin bacteria can affect hair loss and new treatments targeting these bacteria may prevent balding without sexual side effects.
    The document from 2019 explores the connection between the skin microbiome and hair disorders, noting that microbial communities are influenced by physiological factors and remain generally stable over time. It details how alterations in the microbiome contribute to conditions like acne and hidradenitis suppurativa, and suggests that the microbiome could be utilized in treating hair disorders such as alopecia universalis and androgenetic alopecia. The document also proposes a novel treatment for pattern baldness by genetically engineering P. acnes to degrade testosterone, thereby reducing dihydrotestosterone (DHT) and potentially preventing hair loss without the sexual side effects associated with current treatments like finasteride.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 9 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community DHT Harms Scalp Microbiome: DHT Itch is REAL

      in Research/Science  407 upvotes 1 month ago
      Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

      community How uninformed the general public is about hair loss

      in Chat  314 upvotes 1 year ago
      The conversation highlights the general public's lack of knowledge about hair loss, with various ineffective remedies suggested, such as not wearing hats or using hair fibers. The only effective treatments mentioned for male pattern baldness are medications like minoxidil and finasteride, and hair transplants.

      community Just passed by a homeless guy!

      in Chat  190 upvotes 2 months ago
      Hair loss treatments include finasteride, minoxidil, alfatradiol, vitamins, red light therapy, ketoconazole shampoo, meditation, green tea, leg workouts, and silk pillows. Genetics is emphasized as the primary factor in hair health, with some humor about unconventional methods like drug use affecting hair loss.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

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