Pentacyclic Triterpenoid Maslinic Acid Promotes Hair Growth Comparable to Minoxidil: A New Insight on the Potential Involvement of Cilia Activity

July 2025 in “ OPAL (Open@LaTrobe) (La Trobe University) ”

Aprill Kee Oliva Mizushima (21782980), Meryem Bouhoute (21782983), Meriem Bejaoui (10191785), Farhana Ferdousi (5791316), Mitsutoshi Nakajima (2440216), Hiroko Isoda (486330)

TLDR Maslinic acid from olive extracts promotes hair growth like minoxidil.

The study investigates the effects of maslinic acid, a component of olive extracts, on hair growth, finding it comparable to minoxidil in promoting hair growth in mice. Maslinic acid accelerates anagen induction and increases protein levels of CTNNB1 and VEGF, while upregulating trichogenic genes such as CTNNB1, ALPL, and FGF1. It activates key pathways like Wnt, Notch, MAPK, and angiogenesis. The study also highlights a potential link between hair growth and cilia activity, as maslinic acid upregulates the ciliogenesis-promoting gene Iqcb1, and inhibiting cilia activity downregulates CTNNB1. The findings suggest maslinic acid stimulates hair growth through the Wnt/β-catenin pathway and ciliary gene activity.

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Pentacyclic Triterpenoid Maslinic Acid Promotes Hair Growth Comparable to Minoxidil: A New Insight on the Potential Involvement of Cilia Activity

research Pentacyclic Triterpenoid Maslinic Acid Promotes Hair Growth Comparable to Minoxidil: A New Insight on the Potential Involvement of Cilia Activity

July 2025 in “ACS Pharmacology & Translational Science”

Maslinic acid from olive extracts promotes hair growth like minoxidil.

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