Lower Urinary Tract Symptoms in Men
July 2025
in “
JAMA
”
Studysummary This review discusses various treatment options for lower urinary tract symptoms in men, including behavioral, pharmacologic, and surgical interventions, and reports no new clinical results; the authors emphasize first-line therapy with behavioral and pharmacologic approaches.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
Lower urinary tract symptoms (LUTS) in men, affecting up to 40% of those over 50, are often due to benign prostatic hyperplasia (BPH) or an overactive bladder detrusor. These symptoms can significantly impact quality of life and lead to complications like urinary retention. First-line treatments include behavioral therapies and medications such as α-blockers, 5α-reductase inhibitors, and phosphodiesterase inhibitors, which can improve symptoms and prevent progression. Combination therapies are more effective than monotherapy. Surgical options, including transurethral resection and minimally invasive procedures, are effective for refractory cases, with varying complication rates and retreatment needs.
