Recent Developments in Luteolin-Loaded Nanoformulations for Enhanced Anti-Carcinogenic Activities: Insights from In Vitro and In Vivo Studies

    Muhammad Redza Fahmi Mod Razif, Susie Chan, Yik-Ling Chew, Masriana Hassan, Shairyzah Ahmad Hisham, Shamima Abdul Rahman, Chun Wai Mai, Michelle Yee Mun Teo, Phei Er Kee, Kuan Shiong Khoo, Siew Keah Lee, Kai Bin Liew
    TLDR Luteolin-loaded nanoformulations could improve cancer treatment by enhancing luteolin's effectiveness.
    This review highlights the potential of luteolin, a flavonoid with anti-carcinogenic properties, as a safer alternative to traditional chemotherapy, which often causes side effects like hair loss. Despite its benefits, luteolin's therapeutic potential is limited by poor bioavailability and solubility. The review examines how encapsulating luteolin in nanoformulations can enhance its effectiveness, offering a promising strategy for cancer treatment. By comparing the efficacy of luteolin with and without nanoformulations, the review suggests that luteolin-loaded nanoformulations could improve cancer care and outcomes globally.
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