Loose Anagen Syndrome in One Identical Twin Girl

Loose anagen syndrome (LAS) is a hair disorder characterized by insufficient anchoring of the hair follicle to the scalp due to mutations in the gene encoding keratin 6. This case study presented a 2-year-old identical twin girl with type B LAS, which manifests as unruly, uncombable hair with diminished growth. Her identical twin sister showed no hair abnormalities. The diagnosis was confirmed through a painless hair pull test, revealing more than 70% anagen hairs with ruffled cuticles under light microscopy. The family was reassured about the self-limited nature of the condition, alleviating their anxiety and avoiding unnecessary diagnostic tests.