Langerhans' Cells in Hair Follicles of the Depigmenting C57Bl/Ler-Vit.Vit Mouse: A Model for Human Vitiligo

The study investigated the role of Langerhans' cells in the depigmentation process of C57Bl/Ler-vit vit mice, which served as a model for human vitiligo. These mice exhibited a loss of pigmentation in their fur and skin over time. Researchers quantified Langerhans' cells in various skin areas during and after depigmentation. They found that the number of Langerhans' cells was normal during depigmentation and increased after depigmentation, suggesting these cells were not involved in melanocyte destruction. Additionally, the study noted a higher density of Langerhans' cells in hair follicle epithelium compared to interfollicular skin. The findings indicated that Langerhans' cells were likely not responsible for depigmentation in this mouse model.