L-Selectin and Adiponectin as Novel Biochemical-Immune Markers for the Response of Infertile Polycystic Ovary Syndrome Patients to Metformin Treatment

This study investigated the potential of L-Selectin and adiponectin as biochemical-immune markers in differentiating between Metformin-treated and untreated PCOS patients. The study involved 90 women divided into three groups: 30 treated for infertility due to PCOS, 30 diagnosed with PCOS, and 30 healthy controls. Results showed significant differences in L-Selectin and adiponectin levels among the groups, with a positive correlation between these markers in treated PCOS patients and healthy women, but not in untreated PCOS patients. Adiponectin demonstrated high sensitivity (97%) and specificity (97%) in the Metformin-treated group, suggesting these markers could effectively distinguish between treated and untreated PCOS patients.