Studies of the Components of an Oral Contraceptive Agent in Albino Rats: Progestogenic Component and Comparison of Effects of the Components and the Combined Agent
July 1980
in “
Journal of Toxicology and Environmental Health
”
norethindrone acetate progestogenic component alopecia testicular atrophy gonadal atrophy uterine changes adrenal gland weights ovarian atrophy liver enlargement cystic mastopathy uterine polyps liver neoplastic nodules hair loss testicle shrinkage ovary shrinkage liver growth breast cysts uterus growths liver tumors
Studysummary This study found that feeding norethindrone acetate to albino rats over two years caused various dose-related health effects, such as growth retardation and liver changes, but did not increase overall tumor incidence.
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