Keyora Integrated Nutritional Modulation of the Redox–NO–Androgen Axis in Male Endocrine, Reproductive, and Metabolic Disorders

The study explores the interconnected pathophysiological mechanism known as the Redox–NO–Androgen Axis, which is implicated in male endocrine, reproductive, and metabolic disorders such as androgenic alopecia. This axis involves oxidative stress, nitric oxide deficiency, androgenic dysregulation, and mitochondrial impairment, leading to multi-organ decline. The research aims to develop a nutritional intervention model using antioxidants, endothelial cofactors, endocrine regulators, and mitochondrial enhancers to restore balance in oxidative-inflammatory processes, energy metabolism, and androgenic activity. By targeting specific signaling pathways, the study seeks to demonstrate how nutritional modulation can restore mitochondrial, endothelial, and hormonal homeostasis, offering a preventive and restorative approach to male health optimization.