Episodes of Keratitis During Treatment with Baricitinib for Alopecia Areata

    March 2025 in “ Skin Appendage Disorders ”
    Dorottya Gódor, Anastasia Therianou
    From the encyclopedia
    Baricitinib →

    JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

    Alopecia Areata →

    autoimmune disorder causing patchy hair loss

    Studysummary This literature review on JAK inhibitors reports that ocular side effects are rare but could be significant, with an inability to establish a causal link. Clinicians are advised to monitor such adverse events and report them to drug safety agencies. Our plain-language summary of this paper — not a Tressless recommendation.
    The document discusses the potential ocular side effects associated with the use of JAK inhibitors, such as Baricitinib, in treating alopecia areata. Although these side effects, including episodes of keratitis, are rare, they are not unheard of. A causal link between JAK inhibitors and ocular side effects has not been established. Clinicians are advised to be vigilant about these possible adverse events and report them to drug safety agencies. In some cases, discontinuing the drug and switching to an alternative treatment may be necessary.
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